Au centre de l'intrigue du premier volet, nous retrouvons à nouveau Joel et Ellie plus déterminés que jamais à éradiquer les infectés jusqu'au dernier. Se déroulant à nouveau dans un monde post apocalyptique, le duo toujours aussi soudé devra prendre les décisions qui s'imposent afin de survivre un seul jour de plus à cette pandémie.
She gave my mother such a turn, that I have always been convinced I am indebted to Miss Betsey for having been born on a Friday. The word was appropriate to the moment. My mother was so much worse that Peggotty, coming in with the teaboard and candles, and seeing at a glance how ill she was, - as Miss Betsey might have done sooner if there had been light enough, - conveyed her upstairs to her own room with all speed; and immediately dispatched Ham Peggotty, her nephew, who had been for some days past secreted in the house, unknown to my mother, as a special messenger in case of emergency, to fetch the nurse and doctor.
