Après la défaite des Mavericks dans les épisodes précédents, les robots vivent en paix avec les humains. Mais les Mavericks d'origine reviennent à la charge et menacent l'équilibre. Mega Man et Zero sont rappelés sur le devant de la scène pour contrer la nouvelle attaque. Mega Man X3 sur Super Nes propose 8 niveaux d'action plates-formes qui conduisent tous vers un boss différent à affronter.
She gave my mother such a turn, that I have always been convinced I am indebted to Miss Betsey for having been born on a Friday. The word was appropriate to the moment. My mother was so much worse that Peggotty, coming in with the teaboard and candles, and seeing at a glance how ill she was, - as Miss Betsey might have done sooner if there had been light enough, - conveyed her upstairs to her own room with all speed; and immediately dispatched Ham Peggotty, her nephew, who had been for some days past secreted in the house, unknown to my mother, as a special messenger in case of emergency, to fetch the nurse and doctor.